Chemicals are a central aspect of the plastics issue. Although there is a wealth of scientific information on plastic chemicals and polymers to inform policymakers, implementing this evidence is challenging because information is scattered and not easily accessible. The PlastChem report and database address this issue by comprehensively and consistently synthesizing the state of the science on plastic chemicals, including their hazard properties, and their presence in polymers. The state-of-the-science report provides the publicly available evidence to inform policy development that protects public health and the environment.